Hairy cell leukaemia
Adult: 3 million units daily for 16-24 wk. Maintenance: 3 million units 3 times/wk. May continue treatment for up to 24 wk.
Subcutaneous
AIDS-related Kaposi's sarcoma
Adult: In an escalating dose of 3 million units daily for 3 days, 9 million units daily for 3 days, 18 million units daily for 3 days, and 36 million units daily, if tolerated, on days 10-84. thereafter the max tolerated dose (up to 36 million units) may be given 3 times wkly.
Subcutaneous
Chronic hepatitis C
Adult: 3-4.5 million units 3 times wkly for 6 mth when used with ribavirin. As monotherapy: Initial: 3-6 million units 3 times wkly for 6 mth followed by 3 million units 3 times wkly for an additional 6 mth, or 3 million units 3 times wkly for 12 mth.
Subcutaneous
Renal cell carcinoma
Adult: As an adjunct to cytotoxic chemotherapy: In an escalating dose of 3 million units 3 times wkly for 1 wk, then 9 million units 3 times wkly for 1 wk, then 18 million units 3 times wkly thereafter for 3-12 mth.
Subcutaneous
Cutaneous T-cell lymphoma
Adult: In an escalating dose of 3 million units daily for 3 days, then 9 million units daily for 3 days, and then 18 million units daily to complete 12 wk of treatment. Thereafter, the max tolerated dose (up to 18 million units) is given 3 times wkly for at least 12 mth in responders.
Subcutaneous
Chronic myeloid leukaemia
Adult: In an escalating dose of 3 million units daily for 3 days, 6 million units daily for 3 days, and 9 million units daily thereafter. For responders after 12 wk: Continue treatment until a complete haematological response is achieved or for a max of 18 mth; for those who achieve a complete haematological response: Continue on 9 million units daily (at least 9 million units 3 times wkly) in order to achieve a cytogenetic response.
Subcutaneous
Chronic hepatitis B
Adult: 2.5-5 million units/m2 3 times/wk for 4-6 mth.
Subcutaneous
Follicular lymphoma
Adult: As an adjunct to chemotherapy: 6 million units/ m2 daily on days 22-26 of each 28-day chemotherapy cycle.
Subcutaneous
Melanoma
Adult: 3 million units 3 times/wk for 18 mth. Start treatment no later than 6 wk after surgery.